In November 2007, Laboratories Dom AVMM AG (Swiss Registration No. CH-170.3.030.727-5), pioneers in Research & Development specializing in in-depth Live Cell Therapy and Placental Therapy went a step further by introducing an additional Vegetal Placenta in 'Cosmeceutical Form' (Injectible Form) to complement its existing 'Supplement Form' (Capsule Form) range. This New Cosmeceutical Range was researched, developed, manufactured and approved in Switzerland under stringent Swiss GMP (Good Manufacturing Practices) under the name of MFIII of Switzerland Total Skin Rejuvenation & Revitalization Program.

MFIII Vegetal Placenta Injectibles is manufactured according to an unique process, using state-of-the art molecular fractionation technology. The process is performed at controlled temperature with sophisticated ultra filtration units to allow for the selection of specific molecules and to ensure the maintenance of their potency. The manufacturing steps are performed in accordance with the current provisions for Swiss Good Manufacturing Practice (GMP) ensuring a very high quality product.

The Swiss Difference in
MFIII Vegetal Placenta Injectibles

The closely guarded Swiss MFIII Vegetal Placenta extraction method via 'Cold Processing' and the special manufacturing process, maintains the bio activeness of the Vegetal Placenta, unlike traditional or conventional methods.

The traditional method used in Asia required constant drying, grounding into powdered form and risked the collection of heavy metals while modern conventional methods of lyophilization with the application of strong vacuum suction pressure to squeeze water content damages the cell membrane of the placenta. Furthermore, pasteurization or sterilization methods with heat up to 125 C cause changes to the structure of the molecules and dramatically reduces the efficacy of the placentas.

MFIII VP Injectibles maintains the highest levels of bio activeness and also has the following key features: (See below for further explanation).

Supports Healthy MMP (see below for details) activity that enhances the metabolic activity of skin cells and proteins thus effectively reducing wrinkles, sagging and decreasing scar tissue.
Lightening or toning effects on skin pigmentation. This is made possible due to the existence of Glutathione (GSH) found in MFIII VP Injectibles.

Boosts your immune system, metabolism and helps detoxification which are naturally properties of GSH giving you a healthier, more beautiful and firm body. These provide amazing skin rejuvenation and anti aging benefits. In an internal physiological scientific study conducted on human volunteers, the cellular turn-over was measured by the DHA method or the disappearance of the skin's artificial color allowing the measurement of the rate of exfoliation and coenocytes turn-over. After using the product diluted at 50% for 11 days, the cellular turn-over had been increased by a minimum of 26%.

MFIII VP Injectibles comes in sets of 10 vials (ampoules), 4 ml each and can be directly applied on the skin (particularly the face and neck area) or preferably injected intramuscularly or intravenously (one vial daily).

MFIII VP Injectibles is a composition that will work as anti-MMPs, consolidating the extra cellular matrix (ECM) and amino acids that are used to produce new proteins such as collagen in the very specific way skin is structured.

What are Matrix Metalloproteinase (MMPs)? Proteins such as collagen, elastin and others are linked with others macromolecules such as glycoaminoglycans to form the extra cellular matrix (ECM) components of all solid body tissues. Examples include cartilage, the fibrous sheaths of muscles, tendons and ligaments, and the dermal layer of the skin. The ECM components are in constant renewal, or turnover, a process based on an equilibrium between synthesis and degradation. Collagen fibers are synthesized by cells such as skin fibroblasts.

In addition to their anabolic activity, chondrocytes and fibroblasts also produce and secrete enzymes known as collagenase or matrix metalloproteinase (MMPs). MMPs represent a special class of enzymes that target and cleave the fibrous proteins of the ECM. Almost paradoxically, chondrocytes and fibroblasts also produce inhibitors of MMPs. These inhibitors are important in restraining the degradative action of MMPs. A balance must therefore exist between these two opposite cellular activities in order to maintain or restore tissues matrix integrity.

MMPs are capable of degrading all kinds of extra cellular matrix proteins despite their role in maintaining the integrity of the skin and other tissues, MMPs have also been shown to be involved in angiogenesis (Blood vessel formation, which usually accompanies the growth of malignant tissue).

With aging and in various conditions, the metabolic activity of cells such as fibroblasts may become disturbed. Such a disturbance may affect the equilibrium between production and breakdown of extra cellular matrice (Murphy and Reynolds, 1993). In these conditions, the balance between MMPs and inhibitor of MMPs is no longer respected, so that in most cases, the enzymatic activity of MMPs predominates. Aging and long term sunlight exposures are all factors associated with an increased enzymatic activity of MMPs (Fischer, 1997). This activity eventually leads to the degradation of the collagen fiber meshwork.

Before Treatment	After Treatment

Age-related degradation of the extra-cellular matrix is closely associated with skin wrinkling and sagging. The effects of age-related increase in the activity of MMPs and collagenase is most observable on the skin.

In addition, the premature appearance of wrinkles and sagging are linked to long-term sunlight exposure (Fisher, 1997) and cigarette smoking (Kadunce, 1991).

Aging is a natural and inevitable process. However, the damages caused by age-related degeneration of extra-cellular matrix can be modulated if attempts are made to reestablish and maintain the equilibrium between extra-cellular matrix production and the enzymatic activity of MMPs.

MFIII VP Injectibles Also Has Some Lightening Effects On Pigmentation

What is GSH?

GSH is the most powerful naturally occurring antioxidant in human beings. It has multiple roles. GSH protects your vision, boosts your immune system, helps turn carbohydrates into energy, and prevents the buildup of oxidized fats. Many clinical studies have shown that GSH may address some of the major health issues of today such as diabetes, heart disease, strokes, asthma, hepatitis and the diseases associated with aging such as Alzheimer's and arthritis.

GSH, a small molecule found in almost every cell, is a compound classified as a tripeptide made of three amino acids: L-cysteine, glutamic acid, and glycine. Each and every cell in the body uses these raw ingredients to manufactures GSH. The GSH in each cell has numerous functions. The three most important jobs are antioxidation, immunization boosting and detoxification. GSH is also found in every part of the body, especially the lungs, intestinal tract, and liver. The body produces and stores the largest amounts of GSH in the liver, where it is used to detoxify harmful compounds so that they can be removed from the body through bile. The liver also supplies GSH directly to red and white blood cells in the bloodstream helping keep red blood and white blood cells healthy to maximize the disease-fighting power of the immune system. GSH also appears to have an anti-aging affect on the body. GSH levels decline with age, and a lack of glutathione has been shown to leave the body more vulnerable to damage by free radicals, thus speeding up oxidation (deterioration) of the body.

MFIII VP Injectibles has the best available raw form of GSH and is specially blended with two other active ingredients in a proprietary concoction under specific temperatures and conditions to attain optimum effectiveness with minimum application of heat.

Swiss Authorities Certification

MFIII VP TSRRP is originally manufactured and packed in Switzerland with full conformity to international stringent standards of GMP (Good Manufacturing Practice) and was tested and approved by Swiss Medic and obtained the Swiss Public Health Authorities approval.

Swiss GMP (Good Manufacturing Practice) Swiss Medic Certification No. 06-1258	Swiss Approval No: 07-0371-001 Approval Name: MFIII Vegetal Placenta Injectibles (Total Skin Rejuvenation & Revitalization Program) under Swiss Testing STS 347 Swiss Inspection SIS 077

Main Ingredients

Fresh Vegetal Placenta comprises L-Asparagine, L-Threonine, L-Serine, L-Glutamic Acid, L-Proline, L-Alanine, L-Leucine, L-Lysine, L-Arginine, Sodium Chloride, Dextrose, L-Methionine, L-Glutathione, Thiamine, Riboflavine Hydrochlorure, Methylparaben and Purified water.